David J Rawlings Selected Research

Bruton type agammaglobulinemia

1/2022	Health-Related Quality of Life in 91 Patients with X-Linked Agammaglobulinemia.
3/2021	Effective, safe, and sustained correction of murine XLA using a UCOE-BTK promoter-based lentiviral vector.
6/2014	Progressive engineering of a homing endonuclease genome editing reagent for the murine X-linked immunodeficiency locus.
4/2012	Deficient expression of a B cell cytoplasmic tyrosine kinase in human X-linked agammaglobulinemia. 1993.
3/2010	B cell-specific lentiviral gene therapy leads to sustained B-cell functional recovery in a murine model of X-linked agammaglobulinemia.
5/2009	Bruton's tyrosine kinase revealed as a negative regulator of Wnt-beta-catenin signaling.
9/2004	Sustained correction of B-cell development and function in a murine model of X-linked agammaglobulinemia (XLA) using retroviral-mediated gene transfer.

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David J Rawlings Research Topics

Disease

10	Systemic Lupus Erythematosus (Libman-Sacks Disease) 01/2021 - 01/2010
10	Autoimmune Diseases (Autoimmune Disease) 01/2020 - 09/2011
7	Bruton type agammaglobulinemia 01/2022 - 09/2004
6	Neoplasms (Cancer) 01/2021 - 08/2002
6	Hemophilia A (Haemophilia) 04/2015 - 07/2004
5	Infections 01/2021 - 06/2005
4	Wiskott-Aldrich Syndrome 01/2020 - 11/2008
3	Immune System Diseases (Immune Disorders) 03/2021 - 11/2006
3	Inflammation (Inflammations) 01/2019 - 03/2012
3	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 09/2017 - 05/2013
2	Lupus Nephritis 01/2021 - 10/2018
2	Thrombocytopenia (Thrombopenia) 01/2020 - 11/2009
2	Reinfection 10/2018 - 01/2016
2	B-Cell Lymphoma (Lymphoma, B Cell) 01/2018 - 08/2002
2	Rheumatoid Arthritis 09/2017 - 05/2013
2	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 09/2017 - 02/2003
2	Virus Diseases (Viral Diseases) 07/2017 - 02/2014
2	HIV Infections (HIV Infection) 08/2016 - 09/2015
2	Bone Resorption 04/2013 - 09/2006
2	Bacterial Infections (Bacterial Infection) 03/2010 - 09/2004
1	Philadelphia Chromosome 01/2022
1	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 01/2022
1	Sepsis (Septicemia) 12/2021
1	COVID-19 01/2021
1	Common Variable Immunodeficiency 01/2021
1	Sickle Cell Anemia (Hemoglobin S Disease) 03/2019
1	Thalassemia 03/2019
1	Multiple Sclerosis 01/2019
1	Colitis 01/2019
1	Hemoglobinopathies 01/2019
1	Arthritis (Polyarthritis) 01/2018
1	Protein Deficiency 01/2018
1	Crohn Disease (Crohn's Disease) 09/2017
1	Atherosclerosis 12/2016
1	Light Fixation Seizure Syndrome 01/2016
1	Type 1 Hyper-IgM Immunodeficiency Syndrome 01/2016
1	Malaria 01/2016
1	Cytopenia 09/2015
1	Hemorrhage 04/2015
1	Graft vs Host Disease (Graft-Versus-Host Disease) 12/2014
1	Lymphopenia (Lymphocytopenia) 10/2014
1	Inborn Genetic Diseases (Disease, Hereditary) 08/2014
1	Glomerulonephritis 05/2014
1	Primary Immunodeficiency Diseases 02/2014
1	Graves Disease (Basedow Disease) 05/2013

Drug/Important Bio-Agent (IBA)

7	AutoantibodiesIBA 01/2021 - 05/2014
6	AntibodiesIBA 10/2018 - 09/2008
6	Factor VIII (Coagulation Factor VIII)IBA 04/2015 - 07/2004
5	Agammaglobulinaemia Tyrosine KinaseIBA 01/2022 - 09/2004
4	Proteins (Proteins, Gene)FDA Link 01/2018 - 11/2008
3	Monoclonal AntibodiesIBA 01/2021 - 09/2008
3	CytokinesIBA 12/2018 - 03/2012
3	Immunoglobulin M (IgM)IBA 10/2018 - 01/2016
3	Immunoglobulins (Immunoglobulin)IBA 01/2016 - 09/2004
3	DNA (Deoxyribonucleic Acid)IBA 02/2011 - 07/2004
2	Cytokine Receptors (Cytokine Receptor)IBA 01/2022 - 01/2021
2	Antiviral Agents (Antivirals)IBA 01/2021 - 02/2011
2	RNA (Ribonucleic Acid)IBA 01/2021 - 07/2017
2	InterferonsIBA 01/2021 - 07/2017
2	VaccinesIBA 01/2020 - 10/2018
2	Fetal Hemoglobin (Hemoglobin F)IBA 03/2019 - 01/2019
2	Transcription Activator-Like Effector NucleasesIBA 03/2019 - 02/2014
2	Amino Acids FDA Link 01/2019 - 07/2017
2	Non-Receptor Type 22 Protein Tyrosine PhosphataseIBA 01/2019 - 09/2017
2	Antigen-Antibody Complex (Immune Complex)IBA 10/2018 - 05/2014
2	CCR5 Receptors (CCR5 Receptor)IBA 08/2016 - 09/2015
2	Thymic Stromal LymphopoietinIBA 03/2012 - 01/2009
2	Interleukin-10 (Interleukin 10)IBA 01/2010 - 02/2003
2	NF-kappa B (NF-kB)IBA 11/2006 - 08/2002
1	Interleukin-7 (Interleukin 7)IBA 01/2022
1	Phosphoric Monoester Hydrolases (Phosphatases)IBA 12/2019
1	Hemoglobins (Hemoglobin)IBA 03/2019
1	Dextran SulfateIBA 01/2019
1	Proline (L-Proline)FDA Link 01/2019
1	Alanine (L-Alanine)FDA Link 01/2019
1	B-Cell Activating FactorIBA 10/2018
1	B-Cell Activation Factor ReceptorIBA 10/2018
1	dectin 1IBA 01/2018
1	GlucansIBA 01/2018
1	Prednisolone (Predate)FDA LinkGeneric 07/2017
1	Chimeric Antigen ReceptorsIBA 03/2017
1	Immunoglobulin G (IgG)IBA 12/2016
1	EpitopesIBA 12/2016
1	LipidsIBA 12/2016
1	oxidized low density lipoproteinIBA 12/2016
1	CD40 Ligand (CD40L)IBA 01/2016
1	PlasticsIBA 01/2016
1	Neutralizing AntibodiesIBA 04/2015
1	Methotrexate (Mexate)FDA LinkGeneric 12/2014
1	Tacrolimus (Prograf)FDA LinkGeneric 12/2014
1	Nucleic AcidsIBA 05/2014
1	Interleukin-17 (Interleukin 17)IBA 05/2013
1	Protein Tyrosine PhosphatasesIBA 05/2013
1	Peptide Hydrolases (Proteases)FDA Link 04/2013
1	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 04/2012

Therapy/Procedure

7	Therapeutics 01/2020 - 09/2008
2	Cell Transplantation 01/2020 - 11/2010
2	Transplantation 10/2014 - 08/2014
1	Ligation 12/2021
1	Punctures 12/2021